Anti-Aging & Longevity
Cellular health and healthspan optimization
Medical Disclaimer
Compounds being studied for their potential to slow biological aging, improve cellular resilience, and extend healthspan. This is a rapidly evolving field with varying levels of evidence.
Protocol Map
Compounds organized by evidence tier. Foundation compounds have the strongest clinical support. Emerging compounds show promise but lack robust human data.
Foundation
mTOR inhibition for longevity
The most robust longevity compound in preclinical research. The NIA Interventions Testing Program showed consistent lifespan extension in mice. Human data are limited to observational studies and small trials exploring intermittent low-dose protocols.
Literature dosing: 1-6 mg weekly oral -- ITP dosing data; human longevity dosing is investigational
Metabolic health and AMPK activation
The TAME (Targeting Aging with Metformin) trial is ongoing to evaluate metformin as a geroprotective agent. Decades of safety data in diabetic populations. Observational data suggest reduced all-cause mortality in diabetic users compared to non-diabetic controls.
Commonly Added
Cellular energy and DNA repair
NAD+ levels decline with age. Precursor supplementation (NMN, NR) and direct NAD+ administration are being studied for effects on sirtuin activity, mitochondrial function, and DNA repair. Human longevity data are not yet available.
Age-related hormone decline management
Testosterone levels decline approximately 1-2% per year after age 30. Replacement in men with diagnosed deficiency is associated with improvements in bone density, lean mass, mood, and metabolic markers.
Emerging
Mitochondrial electron carrier
Acts as an alternative electron carrier in the mitochondrial electron transport chain. Preclinical data show improved mitochondrial function and neuroprotection. Human longevity data are preliminary.
Growth hormone axis support
GH declines with age (somatopause). Secretagogues stimulate endogenous GH release, which may support body composition, skin quality, and recovery. The relationship between GH/IGF-1 and longevity is complex and potentially dose-dependent.
Recommended Monitoring
Lab work and clinical assessments commonly recommended when pursuing this goal. Your provider will determine the appropriate testing schedule for your situation.
| Test | Frequency | Purpose |
|---|---|---|
| Fasting Insulin | Baseline, then every 6 months | Key marker of metabolic health and insulin sensitivity |
| IGF-1 | Baseline, then every 6 months | Monitor growth hormone axis; excessively high levels may be counterproductive for longevity |
| hsCRP | Baseline, then every 6 months | Systemic inflammation marker correlating with biological aging |
| CBC with Differential | Baseline, then every 6 months | Immune cell counts; rapamycin requires monitoring of white blood cell levels |
| Comprehensive Metabolic Panel | Baseline, then every 6 months | Liver and kidney function, particularly important with rapamycin and metformin |
| Lipid Panel (advanced) | Baseline, then annually | ApoB and Lp(a) provide better cardiovascular risk stratification than standard lipids |
| HbA1c | Baseline, then annually | Long-term glycemic control and metabolic aging marker |
| Homocysteine | Baseline, then annually | Elevated levels associated with cardiovascular disease and cognitive decline |
Lifestyle Foundations
Caloric awareness without chronic restriction supports metabolic flexibility. Time-restricted eating (12-16 hour overnight fast) may complement mTOR-modulating strategies. Regular exercise combining resistance training and zone 2 cardio is the single most evidence-backed longevity intervention. Sleep optimization (7-9 hours, consistent schedule) is non-negotiable for cellular repair. Stress management practices and strong social connections are associated with longer healthspan in epidemiological data.
Related Goals
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The compounds on this page require medical supervision and prescriptions. A qualified provider can evaluate whether these approaches are appropriate for you.
Explore Practical Guides →Important Disclaimer
The information provided on this page is for educational and informational purposes only. It is not intended as, and should not be construed as, medical advice, diagnosis, or treatment. The compounds, dosages, and protocols discussed are summaries of published research and do not constitute prescriptions or treatment plans. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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