Cognitive Function
Supporting brain health and mental performance
Medical Disclaimer
Compounds being studied for neuroprotection, cognitive enhancement, and brain health maintenance. This is an area with emerging evidence and significant research interest.
Protocol Map
Compounds organized by evidence tier. Foundation compounds have the strongest clinical support. Emerging compounds show promise but lack robust human data.
Foundation
Mitochondrial support and neuroprotection
At low doses (0.5-4 mg/kg), methylene blue acts as an alternative electron carrier in mitochondria and has shown neuroprotective effects in preclinical models. Human studies in Alzheimer disease and traumatic brain injury are ongoing. Has FDA approval at higher doses for methemoglobinemia.
Commonly Added
Neuronal energy metabolism
NAD+ is critical for neuronal energy production and DNA repair. Brain NAD+ levels decline with age. Nasal delivery and injection are being explored for more direct CNS effects compared to oral precursors. Human cognitive outcome data are preliminary.
Emerging
GH-mediated brain health
Growth hormone and IGF-1 have neuroprotective and neurogenic effects documented in preclinical models. GH secretagogues may support cognitive function through improved sleep quality (deep sleep is critical for memory consolidation), neurotrophic factor expression, and cerebral blood flow.
Recommended Monitoring
Lab work and clinical assessments commonly recommended when pursuing this goal. Your provider will determine the appropriate testing schedule for your situation.
| Test | Frequency | Purpose |
|---|---|---|
| Cognitive Assessment (MoCA or equivalent) | Baseline, then every 6 months | Standardized tracking of cognitive function over time |
| Comprehensive Metabolic Panel | Baseline, then every 6 months | Metabolic health directly impacts brain function |
| Thyroid Panel | Baseline | Hypothyroidism is a common and treatable cause of cognitive dysfunction |
| Vitamin B12 | Baseline | B12 deficiency causes reversible cognitive impairment |
| Homocysteine | Baseline | Elevated homocysteine is associated with cognitive decline and can be addressed with B vitamins |
| hsCRP | Baseline, then every 6 months | Neuroinflammation marker; systemic inflammation impairs cognitive function |
Lifestyle Foundations
Aerobic exercise is the single most evidence-backed intervention for cognitive health, with studies showing increased BDNF, hippocampal volume, and improved executive function. Sleep is when the glymphatic system clears metabolic waste from the brain -- 7-9 hours of quality sleep is non-negotiable for cognitive maintenance. The Mediterranean and MIND diets have the strongest evidence for cognitive protection. Social engagement and cognitive challenge (learning new skills, not just puzzles) maintain neural plasticity. Chronic stress and elevated cortisol are directly neurotoxic to the hippocampus, making stress management a neuroprotective strategy.
Related Goals
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The compounds on this page require medical supervision and prescriptions. A qualified provider can evaluate whether these approaches are appropriate for you.
Explore Practical Guides →Important Disclaimer
The information provided on this page is for educational and informational purposes only. It is not intended as, and should not be construed as, medical advice, diagnosis, or treatment. The compounds, dosages, and protocols discussed are summaries of published research and do not constitute prescriptions or treatment plans. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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