Hair Restoration
Evidence-based approaches to hair loss
Medical Disclaimer
Compounds with clinical evidence for treating androgenetic alopecia and supporting hair regrowth. Hair loss is multifactorial, and treatment approaches are most effective when started early.
Protocol Map
Compounds organized by evidence tier. Foundation compounds have the strongest clinical support. Emerging compounds show promise but lack robust human data.
Foundation
Vasodilator promoting hair growth
Low-dose oral minoxidil (1.25-5 mg daily) is increasingly used for androgenetic alopecia. Multiple RCTs demonstrate efficacy. Common side effects include hypertrichosis and mild fluid retention. Cardiovascular monitoring recommended.
5-alpha reductase inhibitor
FDA-approved for male pattern hair loss. Reduces DHT by approximately 70%. Long-term studies show sustained benefit over 5+ years. Side effect profile includes a small incidence of sexual side effects that resolve upon discontinuation in most cases.
Commonly Added
Dual 5-alpha reductase inhibitor
Inhibits both type I and type II 5-alpha reductase, reducing DHT by approximately 90%. Head-to-head studies show superiority over finasteride for hair count, though with a higher side effect burden. Used off-label for hair loss.
Emerging
Copper peptide for follicle support
Copper peptides promote angiogenesis and may enlarge hair follicle size. Some clinical data support topical use for hair density improvement. Often combined with microneedling for enhanced penetration.
Recommended Monitoring
Lab work and clinical assessments commonly recommended when pursuing this goal. Your provider will determine the appropriate testing schedule for your situation.
| Test | Frequency | Purpose |
|---|---|---|
| Baseline Photographs (standardized) | Baseline, then every 3-6 months | Objective tracking of hair density and coverage over time |
| DHT (Dihydrotestosterone) | Baseline, then 3 months after starting treatment | Confirm pharmacologic response to 5-alpha reductase inhibitors |
| Total Testosterone / Free Testosterone | Baseline | Rule out hormonal contributors to hair loss |
| Thyroid Panel | Baseline | Thyroid dysfunction is a common reversible cause of hair loss |
| Ferritin | Baseline | Iron deficiency contributes to hair loss, particularly in women |
| Blood Pressure | Monthly for first 3 months if on oral minoxidil | Monitor for hypotensive effects of systemic minoxidil |
Lifestyle Foundations
Nutritional adequacy is the foundation -- iron, zinc, biotin, and vitamin D deficiencies all contribute to hair loss independently of androgens. Stress management is important, as telogen effluvium from chronic stress can compound androgenetic loss. Gentle hair care practices that minimize traction and heat damage preserve existing hair. Scalp massage may modestly improve blood flow to follicles. Patience is essential, as most hair restoration compounds require 6-12 months to show visible results.
Related Goals
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The compounds on this page require medical supervision and prescriptions. A qualified provider can evaluate whether these approaches are appropriate for you.
Explore Practical Guides →Important Disclaimer
The information provided on this page is for educational and informational purposes only. It is not intended as, and should not be construed as, medical advice, diagnosis, or treatment. The compounds, dosages, and protocols discussed are summaries of published research and do not constitute prescriptions or treatment plans. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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