Gut Health
Supporting gastrointestinal function and healing
Medical Disclaimer
Compounds studied for their potential to support GI healing, reduce intestinal inflammation, and improve gut barrier integrity. BPC-157 is the most frequently discussed peptide in this category given its gastric origin.
Protocol Map
Compounds organized by evidence tier. Foundation compounds have the strongest clinical support. Emerging compounds show promise but lack robust human data.
Foundation
Gastric pentadecapeptide for gut healing
Originally isolated from human gastric juice, BPC-157 has extensive preclinical data showing protective and healing effects on the GI tract, including ulcer healing, intestinal anastomosis repair, and anti-inflammatory effects in colitis models. Both oral and injectable routes are studied. Human clinical trials are limited but underway.
Literature dosing: 250-500 mcg SC or oral daily -- based on preclinical dosing models
Commonly Added
Immune modulation and anti-inflammatory
At low doses (1.5-4.5 mg), naltrexone has immunomodulatory effects distinct from its full-dose opioid antagonist action. Clinical data support its use in IBD (Crohn disease), with improvements in mucosal healing and quality of life scores. Mechanism involves transient opioid receptor blockade and subsequent endorphin upregulation.
Emerging
Antioxidant and detoxification support
The body's master antioxidant, glutathione is depleted in many GI conditions. Liposomal oral and IV forms are used to support GI mucosal health and reduce oxidative stress. Some clinical data support its use in inflammatory GI conditions.
Recommended Monitoring
Lab work and clinical assessments commonly recommended when pursuing this goal. Your provider will determine the appropriate testing schedule for your situation.
| Test | Frequency | Purpose |
|---|---|---|
| GI Symptom Assessment (standardized questionnaire) | Baseline, then monthly | Track symptom severity, frequency, and quality of life impact |
| CRP / ESR | Baseline, then every 3 months | Monitor systemic inflammation, particularly relevant for IBD |
| Calprotectin (fecal) | Baseline, then every 3 months if IBD | Specific marker of intestinal inflammation; useful for monitoring disease activity |
| Comprehensive Metabolic Panel | Baseline, then every 6 months | Monitor nutritional absorption and organ function |
| CBC with Differential | Baseline, then every 6 months | Screen for anemia and immune changes |
| Vitamin/Mineral Panel (B12, Iron, Vitamin D) | Baseline, then every 6 months | GI conditions frequently cause micronutrient deficiencies |
Lifestyle Foundations
An anti-inflammatory diet (Mediterranean or elimination-based if food sensitivities are suspected) is the foundation of gut health. Identifying and removing trigger foods through structured elimination provides the substrate for healing. Adequate fiber from diverse plant sources feeds beneficial gut bacteria, though fiber tolerance varies with condition severity. Stress management is critical because the gut-brain axis means chronic stress directly increases intestinal permeability and inflammation. Adequate sleep supports the circadian rhythms of gut bacteria and overnight mucosal repair. Avoiding unnecessary NSAIDs, alcohol, and processed foods reduces ongoing mucosal damage.
Related Goals
Find a Provider
The compounds on this page require medical supervision and prescriptions. A qualified provider can evaluate whether these approaches are appropriate for you.
Explore Practical Guides →Important Disclaimer
The information provided on this page is for educational and informational purposes only. It is not intended as, and should not be construed as, medical advice, diagnosis, or treatment. The compounds, dosages, and protocols discussed are summaries of published research and do not constitute prescriptions or treatment plans. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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